Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 64,778 bioRxiv papers from 287,147 authors.
Genetic stratification of depression in UK Biobank suggests a subgroup linked to age of natural menopause
David M. Howard,
Mark James Adams,
Kylie P Glanville,
Thomas M Werge,
David J Porteous,
Patrick F Sullivan,
Naomi R. Wray,
Cathryn M Lewis,
Andrew M McIntosh
Posted 05 May 2017
bioRxiv DOI: 10.1101/134601
Posted 05 May 2017
Depression is a common and clinically heterogeneous mental health disorder that is frequently comorbid with other diseases and conditions. Stratification of depression may align sub-diagnoses more closely with their underling aetiology and provide more tractable targets for research and effective treatment. In the current study, we investigated whether genetic data could be used to identify subgroups within people with depression using the UK Biobank. Examination of cross-locus correlations was used to test for evidence of subgroups by examining whether there was clustering of independent genetic variants associated with eleven other complex traits and disorders in people with depression. We found evidence of a subgroup within depression using age of natural menopause variants ( P = 1.69 × 10−3) and this effect remained significant in females ( P = 1.18 × 10−3), but not males ( P = 0.186). However, no evidence for this subgroup ( P > 0.05) was found in Generation Scotland, iPSYCH, a UK Biobank replication cohort or the GERA cohort. In the UK Biobank, having depression was also associated with a later age of menopause (beta = 0.34, standard error = 0.06, P = 9.92 × 10−8). A potential age of natural menopause subgroup within depression and the association between depression and a later age of menopause suggests that they partially share a developmental pathway.
- Downloaded 892 times
- Download rankings, all-time:
- Site-wide: 8,855 out of 64,778
- In genetics: 666 out of 3,675
- Year to date:
- Site-wide: 18,054 out of 64,778
- Since beginning of last month:
- Site-wide: 3,860 out of 64,778
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!