Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate
Anna Joanna Jasinska,
Susan K Service,
Christine B Peterson,
Rita M. Cantor,
Lynn A. Fairbanks,
Allison E. Furterer,
Yu S. Huang,
Christopher A. Schmitt,
Matthew J. Jorgensen,
Jay R. Kaplan,
Bronwen L. Aken,
Emily S Wong,
Thomas D. Dyer,
George M Weinstock,
Richard K Wilson,
J. David Jentsch,
Roger P. Woods,
Nelson B. Freimer
Posted 09 Dec 2016
bioRxiv DOI: 10.1101/092874 (published DOI: 10.1038/ng.3959)
Posted 09 Dec 2016
By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs) whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
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