Rxivist logo

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

By Michelle Luciano, Saskia P Hagenaars, Gail Davies, W. David Hill, T-K Clarke, Masoud Shirali, Riccardo E. Marioni, Sarah E. Harris, David C Liewald, Chloe Fawns-Ritchie, AI Campbell, David M Howard, Cathryn Lewis, Catharine R Gale, Y Zeng, BH Smith

Posted 28 Jul 2017
bioRxiv DOI: 10.1101/168906 (published DOI: 10.1038/s41588-017-0013-8)

Neuroticism is a stable personality trait; twin studies report heritability between 30% and 50%, and SNP-based heritability is about 15%. Higher levels of neuroticism are associated with poorer mental and physical health, and the economic burden of neuroticism for societies is high. To date, genome-wide association (GWA) studies of neuroticism have identified up to 11 genetic loci. Here we report 116 significant independent genetic loci from a GWA of neuroticism in 329,821 UK Biobank participants, with replication available in a GWA meta-analysis of neuroticism in 122,867 individuals. Genetic signals for neuroticism were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = .82, SE=.03), major depressive disorder (rg = .69, SE=.07) and subjective wellbeing (rg = -.68, SE=.03) alongside other mental health traits. These discoveries significantly advance our understanding of neuroticism and its association with major depressive disorder.

Download data

  • Downloaded 1,249 times
  • Download rankings, all-time:
    • Site-wide: 7,470 out of 84,692
    • In genetics: 534 out of 4,445
  • Year to date:
    • Site-wide: 27,012 out of 84,692
  • Since beginning of last month:
    • Site-wide: 13,144 out of 84,692

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)