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116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.
Saskia P Hagenaars,
William David Hill,
Sarah E Harris,
David C Liewald,
Mark J Adams,
David M. Howard,
Cathryn M Lewis,
Catharine R Gale,
Andrew M McIntosh,
Ian J Deary
Posted 28 Jul 2017
bioRxiv DOI: 10.1101/168906 (published DOI: 10.1038/s41588-017-0013-8)
Posted 28 Jul 2017
Neuroticism is a stable personality trait; twin studies report heritability between 30% and 50%, and SNP-based heritability is about 15%. Higher levels of neuroticism are associated with poorer mental and physical health, and the economic burden of neuroticism for societies is high. To date, genome-wide association (GWA) studies of neuroticism have identified up to 11 genetic loci. Here we report 116 significant independent genetic loci from a GWA of neuroticism in 329,821 UK Biobank participants, with replication available in a GWA meta-analysis of neuroticism in 122,867 individuals. Genetic signals for neuroticism were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = .82, SE=.03), major depressive disorder (rg = .69, SE=.07) and subjective wellbeing (rg = -.68, SE=.03) alongside other mental health traits. These discoveries significantly advance our understanding of neuroticism and its association with major depressive disorder.
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