Rxivist logo

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

By Michelle Luciano, Saskia Hagenaars, Gail Davies, W. David Hill, T-K Clarke, Masoud Shirali, Riccardo E Marioni, Sarah E Harris, David C Liewald, Chloe Fawns-Ritchie, Mark J Adams, David M Howard, Cathryn Lewis, Catharine Gale, Andrew M McIntosh, Ian J Deary

Posted 28 Jul 2017
bioRxiv DOI: 10.1101/168906 (published DOI: 10.1038/s41588-017-0013-8)

Neuroticism is a stable personality trait; twin studies report heritability between 30% and 50%, and SNP-based heritability is about 15%. Higher levels of neuroticism are associated with poorer mental and physical health, and the economic burden of neuroticism for societies is high. To date, genome-wide association (GWA) studies of neuroticism have identified up to 11 genetic loci. Here we report 116 significant independent genetic loci from a GWA of neuroticism in 329,821 UK Biobank participants, with replication available in a GWA meta-analysis of neuroticism in 122,867 individuals. Genetic signals for neuroticism were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = .82, SE=.03), major depressive disorder (rg = .69, SE=.07) and subjective wellbeing (rg = -.68, SE=.03) alongside other mental health traits. These discoveries significantly advance our understanding of neuroticism and its association with major depressive disorder.

Download data

  • Downloaded 1,520 times
  • Download rankings, all-time:
    • Site-wide: 14,213
    • In genetics: 630
  • Year to date:
    • Site-wide: 48,097
  • Since beginning of last month:
    • Site-wide: 32,356

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide