Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 71,060 bioRxiv papers from 310,082 authors.

116 independent genetic variants influence the neuroticism personality trait in over 329,000 UK Biobank individuals.

By Michelle Luciano, Catharine R Gale, Gail Davies, W. David Hill, Toni-Kim Clarke, Masoud Shirali, Riccardo E. Marioni, Sarah E. Harris, David C Liewald, Chloe Fawns-Ritchie, Mark J. Adams, David M. Howard, Cathryn M. Lewis, Catharine R Gale, Andrew M. McIntosh, Ian J Deary

Posted 28 Jul 2017
bioRxiv DOI: 10.1101/168906 (published DOI: 10.1038/s41588-017-0013-8)

Neuroticism is a stable personality trait; twin studies report heritability between 30% and 50%, and SNP-based heritability is about 15%. Higher levels of neuroticism are associated with poorer mental and physical health, and the economic burden of neuroticism for societies is high. To date, genome-wide association (GWA) studies of neuroticism have identified up to 11 genetic loci. Here we report 116 significant independent genetic loci from a GWA of neuroticism in 329,821 UK Biobank participants, with replication available in a GWA meta-analysis of neuroticism in 122,867 individuals. Genetic signals for neuroticism were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = .82, SE=.03), major depressive disorder (rg = .69, SE=.07) and subjective wellbeing (rg = -.68, SE=.03) alongside other mental health traits. These discoveries significantly advance our understanding of neuroticism and its association with major depressive disorder.

Download data

  • Downloaded 1,151 times
  • Download rankings, all-time:
    • Site-wide: 6,594 out of 71,037
    • In genetics: 513 out of 3,933
  • Year to date:
    • Site-wide: 27,296 out of 71,037
  • Since beginning of last month:
    • Site-wide: 26,932 out of 71,037

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)