Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 62,734 bioRxiv papers from 278,354 authors.
The genetic architecture of osteoarthritis: insights from UK Biobank
Fernando P. Hartwig,
Cindy G Boer,
George C. Babis,
Andre G Uitterlinden,
Joyce B. J. van Meurs,
George Davey Smith,
Mark J. Wilkinson,
Posted 11 Aug 2017
bioRxiv DOI: 10.1101/174755 (published DOI: 10.1038/s41588-018-0079-y)
Posted 11 Aug 2017
Osteoarthritis is a common complex disease with huge public health burden. Here we perform a genome-wide association study for osteoarthritis using data across 16.5 million variants from the UK Biobank resource. Following replication and meta-analysis in up to 30,727 cases and 297,191 controls, we report 9 new osteoarthritis loci, in all of which the most likely causal variant is non-coding. For three loci, we detect association with biologically-relevant radiographic endophenotypes, and in five signals we identify genes that are differentially expressed in degraded compared to intact articular cartilage from osteoarthritis patients. We establish causal effects for higher body mass index, but not for triglyceride levels or type 2 diabetes liability, on osteoarthritis.
- Downloaded 1,136 times
- Download rankings, all-time:
- Site-wide: 5,759 out of 62,734
- In genetics: 460 out of 3,562
- Year to date:
- Site-wide: 21,203 out of 62,734
- Since beginning of last month:
- Site-wide: 30,837 out of 62,734
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!