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Common variants of NRXN1, LRP1B and RORA are associated with increased ventricular volumes in psychosis - GWAS findings from the B-SNIP deep phenotyping study
By
Ney Alliey-Rodriguez,
Tamar A. Grey,
Rebecca Shafee,
Jaya Padmanabhan,
Neeraj Tandon,
Madeline Klinger,
Jonathan Spring,
Lucas Coppes,
Katherine Reis,
Matcheri S Keshavan,
Diane Gage,
Steven McCarroll,
Jeffrey R Bishop,
Scot Hill,
James Reilly,
Rebekka Lencer,
Brett Clementz,
Peter Buckley,
Shashwath Meda,
Balaji Narayanan,
David Glahn,
Godfrey Pearlson,
Elena Ivleva,
Carol Tamminga,
John Sweeney,
David Curtis,
Sarah Keedy,
Judith Badner,
Chunyu Liu,
Elliot S Gershon
Posted 11 Aug 2017
bioRxiv DOI: 10.1101/175489
Schizophrenia, Schizoaffective, and Bipolar Disorders share common illness traits, intermediate phenotypes and a partially overlapping polygenic basis. We performed GWAS on deep phenotyping data, including structural MRI and DTI, clinical, and behavioral scales from 1,115 cases and controls. Significant associations were observed with two cerebrospinal fluid volumes: the temporal horn of left lateral ventricle was associated with NRXN1, and the volume of the cavum septum pellucidum was associated with LRP1B and RORA. Both volumes were associated with illness. Suggestive associations were observed with local gyrification indices, fractional anisotropy and age at onset. This is the first report of common genetic variants associated with these intermediate phenotypes.
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