Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 72,915 bioRxiv papers from 317,450 authors.

Neuroticism is an important risk factor for psychiatric traits including depression, anxiety, and schizophrenia. Previous genome-wide association studies (GWAS) reported 16 genomic loci. Here we report the largest neuroticism GWAS meta-analysis to date (N=449,484), and identify 136 independent genome-wide significant loci (124 novel), implicating 599 genes. Extensive functional follow-up analyses show enrichment in several brain regions and involvement of specific cell-types, including dopaminergic neuroblasts (P=3E-8), medium spiny neurons (P=4E-8) and serotonergic neurons (P=1E-7). Gene-set analyses implicate three specific pathways: neurogenesis (P=4.4E-9), behavioural response to cocaine processes (P=1.84E-7), and axon part (P=5.26E-8). We show that neuroticism's genetic signal partly originates in two genetically distinguishable subclusters (depressed affect and worry, the former being genetically strongly related to depression, rg=0.84), suggesting distinct causal mechanisms for subtypes of individuals. These results vastly enhance our neurobiological understanding of neuroticism, and provide specific leads for functional follow-up experiments.

Download data

  • Downloaded 1,998 times
  • Download rankings, all-time:
    • Site-wide: 2,677 out of 72,916
    • In genetics: 244 out of 4,008
  • Year to date:
    • Site-wide: 23,619 out of 72,916
  • Since beginning of last month:
    • Site-wide: 23,619 out of 72,916

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)