Possible transmission flow of SARS-CoV-2 based on ACE2 features
Sk. Sarif Hassan,
Pabitra Pal Choudhury,
Vladimir N Uversky,
Bruce D Uhal,
Alaa A. A. Aljabali,
Tarek Mohamed Abd El-Aziz,
Gajendra Kumar Azad,
Samendra P Sherchan,
Adam M Brufsky
Posted 09 Oct 2020
bioRxiv DOI: 10.1101/2020.10.08.332452
Posted 09 Oct 2020
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22-42, aa 79-84, and aa 330-393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. ### Competing Interest Statement The authors have declared no competing interest.
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