Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 65,016 bioRxiv papers from 288,163 authors.
Genetic study links components of the autonomous nervous system to heart-rate profile during exercise
Heart rate (HR) response to exercise, as defined by HR-increase upon exercise and HR-recovery after exercise, is an important predictor of mortality and believed to be modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences remains to be elucidated. To investigate this, we performed a large-scale genome wide analysis of HR-increase and HR-recovery in 58,818 individuals. A total of 25 significant independent SNPs in 23 loci (P<8.3x10-9) were associated with HR-increase or HR-recovery, and 36 candidate causal genes were prioritized that were enriched for pathways related to neuron biology. There was no evidence of a causal relationship with mortality or cardiovascular diseases, however, a nominal association with parental lifespan was observed (5.5x10-4) that requires further study. In conclusion, our findings provide new biological and clinical insight into the mechanistic under-pinning of HR response to exercise, underscoring the role of the autonomous nervous system in HR-recovery.
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