A Major Role for Common Genetic Variation in Anxiety Disorders
Kirstin L Purves,
Jonathan RI Coleman,
Sandra M Meier,
Katrina A. S. Davis,
Anders D Børglum,
Shing Wan Choi,
Héléna A. Gaspar,
John M. Hettema,
Andrew M McIntosh,
Preben B Mortensen,
Thomas M Werge,
Kristin K. Nicodemus,
Thalia C Eley
Posted 16 Oct 2017
bioRxiv DOI: 10.1101/203844 (published DOI: 10.1038/s41380-019-0559-1)
Posted 16 Oct 2017
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n = 83 565) and an additional Current Anxiety Symptoms (n= 77 125) analysis. The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2 . Anxiety showed significant genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
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