Heritability of regional brain volumes in large-scale neuroimaging and genetic studies
Joseph G. Ibrahim,
Paul M. Thompson,
Pediatric Imaging, Neurocognition and Genetics (PING),
Peter Van Zijl,
Alzheimer’s Disease Neuroimaging Initiative (ADNI),
Clifford R. Jack,
John Q. Trojanowki,
Arthur W. Toga,
Robert C. Green,
Andrew J Saykin,
Leslie M. Shaw,
M. Marcel Mesulman,
Peter J. Snyder,
Ronald G. Thomas,
Paul M Thompson,
Robert A. Koeppe,
Eric M. Reiman,
Nigel J. Cairns,
Virginia M.Y. Lee,
Posted 25 Oct 2017
bioRxiv DOI: 10.1101/208496 (published DOI: 10.1093/cercor/bhy157)
Posted 25 Oct 2017
Brain genetics is an active research area. The degree to which genetic variants impact variations in brain structure and function remains largely unknown. We examined the heritability of regional brain volumes (p ~ 100) captured by single-nucleotide polymorphisms (SNPs) in UK Biobank (n ~ 9000). We found that regional brain volumes are highly heritable in this study population. We observed omni-genic impact across the genome as well as enrichment of SNPs in active chromatin regions. Principal components derived from regional volume data are also highly heritable, but the amount of variance in brain volume explained by the component did not seem to be related to its heritability. Heritability estimates vary substantially across large-scale functional networks and brain regions. The variation in heritability across regions was not related to measurement reliability. Heritability estimates exhibit a symmetric pattern across left and right hemispheres and are consistent in females and males. Our main findings in UK Biobank are consistent with those in Alzheimers Disease Neuroimaging Initiative (n ~ 1100), Philadelphia Neurodevelopmental Cohort (n ~ 600), and Pediatric Imaging, Neurocognition, and Genetics (n ~ 500) datasets, with more stable estimates in UK Biobank.
- Downloaded 851 times
- Download rankings, all-time:
- Site-wide: 33,408
- In genetics: 1,493
- Year to date:
- Site-wide: 126,416
- Since beginning of last month:
- Site-wide: 138,509
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!