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Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

By Sandra Sanchez-Roige, Pierre Fontanillas, Sarah L. Elson, the 23andMe Research Team, Anita Pandit, Ellen M. Schmidt, Johanna R. Foerster, Gonçalo R Abecasis, Joshua C. Gray, Harriet de Wit, L Davis, James MacKillop, Abraham A. Palmer

Posted 07 Jun 2017
bioRxiv DOI: 10.1101/146936 (published DOI: 10.1038/s41593-017-0032-x)

Delay discounting (DD), which is the tendency to discount the value of delayed versus current rewards, is elevated in a constellation of diseases and behavioral conditions. We performed a genome-wide association study of DD using 23,127 research participants of European ancestry. The most significantly associated SNP was rs6528024 (P = 2.40 x 10-8), which is located in an intron of the gene GPM6B. We also showed that 12% of the variance in DD was accounted for by genotype, and that the genetic signature of DD overlapped with attention-deficit/hyperactivity disorder, schizophrenia, major depression, smoking, personality, cognition, and body weight.

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