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Persistent bacterial coinfection of a COVID-19 patient caused by a genetically adapted Pseudomonas aeruginosa chronic colonizer

By Jiuxin Qu, Zhao Cai, Yumei Liu, XiangKe Duan, Shuhong Han, Yuao Zhu, Zhaofang Jiang, Yingdan Zhang, Chao Zhuo, Yang Liu, Yingxia Liu, Lei Liu, Liang Yang

Posted 06 Aug 2020
bioRxiv DOI: 10.1101/2020.08.05.238998

This study characterized a genetically adapted Pseudomonas aeruginosa small colony variant isolated from a COVID-19 patient who suffered persistent bacterial coinfection and eventually recovered from critical illness. Specification and modification of the isolates discovered at genomic and transcriptomic levels with aligned phenotypic observations indicated that these isolates formed excessive biofilm with elevated quorum sensing systems. ### Competing Interest Statement The authors have declared no competing interest.

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