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Intrinsic neural timescales related to sensory processing: Evidence from abnormal behavioural states

By Federico Zilio, Javier Gomez-Pilar, Shumei Cao, Jun Zhang, Di Zang, Zengxin Qi, Jiaxing Tan, Tanigawa Hiromi, Xuehai Wu, Stuart Fogel, Zirui Huang, Matthias R Hohmann, Tatiana Fomina, Matthis Synofzik, Moritz Grosse-Wentrup, Adrian M Owen, Georg Northoff

Posted 31 Jul 2020
bioRxiv DOI: 10.1101/2020.07.30.229161

The brain exhibits a complex temporal structure which translates into a hierarchy of distinct neural timescales. An open question is how these intrinsic timescales are related to sensory or motor information processing and whether these dynamics have common patterns in different behavioural states. We address these questions by investigating the brain's intrinsic timescales in healthy controls, motor (amyotrophic lateral sclerosis, locked-in syndrome), sensory (anaesthesia, unresponsive wakefulness syndrome), and progressive reduction of sensory processing (from awake states over N1, N2, N3). We employed a combination of measures from EEG resting-state data: auto-correlation window (ACW), power spectral density (PSD), and power-law exponent (PLE). Prolonged neural timescales accompanied by a shift towards slower frequencies were observed in the conditions with sensory deficits, but not in conditions with motor deficits. Our results establish that the spontaneous activity's intrinsic neural timescale is related to specifically sensory rather than motor information processing in the healthy brain. ### Competing Interest Statement The authors have declared no competing interest.

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