Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
By
Raymond K Walters,
Mark J. Adams,
Amy E. Adkins,
Fazil Aliev,
Silviu-Alin Bacanu,
Anthony Batzler,
Sarah Bertelsen,
Joanna M. Biernacka,
Tim B. Bigdeli,
Li-Shiun Chen,
T-K Clarke,
Yi-Ling Chou,
Franziska Degenhardt,
Anna R. Docherty,
Pierre Fontanillas,
Jerome Foo,
Louis Fox,
Josef Frank,
Ina Giegling,
Scott Gordon,
Laura M. Hack,
Annette Hartmann,
Sarah Hartz,
Stefanie Heilmann-Heimbach,
Stefan Herms,
Colin Hodgkinson,
Per Hoffmann,
Jouke-Jan Hottenga,
Martin A. Kennedy,
Mervi Alanne-Kinnunen,
Bettina Konte,
Jari Lahti,
Marius Lahti-Pulkkinen,
lannie ligthart,
Anu-Maria Loukola,
Brion S. Maher,
Hamdi Mbarek,
Andrew M McIntosh,
Matthew B. McQueen,
Yuri Milaneschi,
Teemu Palviainen,
John F. Pearson,
Roseann E. Peterson,
Renato Polimanti,
Samuli Ripatti,
Euijung Ryu,
Nancy L. Saccone,
Jessica E. Salvatore,
Sandra Sanchez-Roige,
Melanie Schwandt,
Richard Sherva,
Fabian Streit,
Jana Strohmaier,
Nathaniel Thomas,
Jen-Chyong Wang,
Bradley T. Webb,
Robbee Wedow,
Leah Wetherill,
Amanda G. Wills,
23andMe Research Team,
Jason D. Boardman,
Danfeng Chen,
Doo-Sup Choi,
William E. Copeland,
Robert C. Culverhouse,
Norbert Dahmen,
Louisa Degenhardt,
Benjamin W. Domingue,
Sarah L. Elson,
Mark A. Frye,
Wolfgang Gäbel,
Marcus Ising,
Emma C. Johnson,
Margaret Keyes,
Falk Kiefer,
John R Kramer,
Samuel Kuperman,
Susanne Lucae,
Michael Lynskey,
Wolfgang Maier,
Karl Mann,
Satu Männistö,
Jeanette Nance McClintick,
Jacquelyn L. Meyers,
Bertram Muller-Myhsok,
John I. Nurnberger,
Aarno Palotie,
Ulrich Preuss,
Katri Räikkönen,
Maureen D. Reynolds,
Monika Ridinger,
Norbert Scherbaum,
Marc Shuckit,
Michael Soyka,
Jens Treutlein,
Stephanie H. Witt,
Norbert Wodarz,
Peter Zill,
Daniel E Adkins,
Joseph M. Boden,
Dorret I. Boomsma,
Laura J. Bierut,
Sandra A. Brown,
Kathleen K. Bucholz,
Sven Cichon,
E. Jane Costello,
Harriet de Wit,
Nancy Diazgranados,
Danielle M Dick,
Johan G. Eriksson,
Lindsay A. Farrer,
Tatiana Foroud,
Nathan A. Gillespie,
Alison M. Goate,
David Goldman,
Richard A. Grucza,
Dana B. Hancock,
Kathleen Mullan Harris,
Andrew C. Heath,
Victor Hesselbrock,
John Hewitt,
Christian Hopfer,
John Horwood,
William Iacono,
Eric O. Johnson,
jaakko a kaprio,
Victor Karpyak,
Kenneth S. Kendler,
Henry R. Kranzler,
Kenneth Krauter,
Paul Lichtenstein,
Penelope A. Lind,
Matt McGue,
James MacKillop,
Pamela A.F. Madden,
Hermine Maes,
Patrik K. E. Magnusson,
Nicholas G Martin,
Sarah E. Medland,
Grant W. Montgomery,
Elliot C. Nelson,
Markus M. Nöthen,
Abraham A. Palmer,
Nancy L. Pedersen,
Brenda W. J. H. Penninx,
Bernice Porjesz,
John P. Rice,
Marcella D.C. Rietschel,
Brien P. Riley,
Richard Rose,
Dan Rujescu,
Pei-Hong Shen,
Judy Silberg,
Michael C. Stallings,
Ralph E. Tarter,
Michael M. Vanyukov,
Scott Vrieze,
Tamara L. Wall,
John B. Whitfield,
Hongyu Zhao,
Benjamin M Neale,
Joel Gelernter,
Howard J. Edenberg,
Arpana Agrawal
Posted 10 Mar 2018
bioRxiv DOI: 10.1101/257311
(published DOI: 10.1038/s41593-018-0275-1)
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest GWAS to date of DSM-IV diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case/control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, N = 46,568; African; N = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; p = 9.8E-13) and African ancestries (rs2066702; p = 2.2E-9). Significant genetic correlations were observed with schizophrenia, ADHD, depression, and use of cigarettes and cannabis. There was only modest genetic correlation with alcohol consumption and inconsistent associations with problem drinking. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and non-pathological drinking behaviors.
Download data
- Downloaded 1,856 times
- Download rankings, all-time:
- Site-wide: 7,298
- In genetics: 362
- Year to date:
- Site-wide: 40,644
- Since beginning of last month:
- Site-wide: 56,201
Altmetric data
Downloads over time
Distribution of downloads per paper, site-wide
PanLingua
News
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!