DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
Jenny van Dongen,
Fiona A. Hagenbeek,
Andreas G. Chiocchetti,
Rosa H. Mulder,
Mark J. Adams,
Rosie M. Walker,
Stewart W Morris,
Leanne K Küpers,
Hill F. Ip,
Bart M. L. Baselmans,
Pashupati Prasad Mishra,
Olivier F. Colins,
Juan R González,
Kristine B. Gutzkow,
Dennis van der Meer,
Gareth E. Davies,
Christine M. Freitag,
Olli T Raitakari,
Stephanie H. Witt,
Nancy L. Pedersen,
Jaakko A. Kaprio,
Terrie E. Moffitt,
Marinus H. van Ijzendoorn,
Caroline L. Relton,
Kathryn L Evans,
Andrew M. McIntosh,
Posted 22 Jul 2020
bioRxiv DOI: 10.1101/2020.07.22.215939
Posted 22 Jul 2020
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta analysis of epigenome wide association studies (EWAS) of aggressive behavior (N 15,324 participants). ### Competing Interest Statement The following authors declare a conflict of interest: Barbara Franke received educational speaking fees from Medice. Andrew M. McIntosh has received research support from Eli Lilly, Janssen and The Sackler Trust and speaker fees from Illumina and Janssen. Christine M. Freitag has received funding by the DFG, BMBF, State of Hessen, and the EU. She receives royalties for books on ASD, ADHD, and MDD.
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