Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles
Catherine Z. Chen,
Marco R. Straus,
Samuel G. Michael,
Gary R Whittaker
Posted 11 Jul 2020
bioRxiv DOI: 10.1101/2020.07.10.197988 (published DOI: 10.1021/acsptsci.0c00112)
Posted 11 Jul 2020
While vaccine development will hopefully quell the global pandemic of COVID-19 caused by SARS-CoV-2, small molecule drugs that can effectively control SARS-CoV-2 infection are urgently needed. Here, inhibitors of spike (S) mediated cell entry were identified in a high throughput screen of an approved drugs library with SARS-S and MERS-S pseudotyped particle entry assays. We discovered six compounds (cepharanthine, abemaciclib, osimertinib, trimipramine, colforsin, and ingenol) to be broad spectrum inhibitors for spike-mediated entry. This work should contribute to the development of effective treatments against the initial stage of viral infection, thus reducing viral burden in COVID-19 patients. ![Figure]</img> ### Competing Interest Statement The authors have declared no competing interest. : pending:yes
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