Rxivist logo

The major genetic risk factor for severe COVID-19 is inherited from Neandertals

By Hugo Zeberg, Svante Pääbo

Posted 03 Jul 2020
bioRxiv DOI: 10.1101/2020.07.03.186296 (published DOI: 10.1038/s41586-020-2818-3)

A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe. ### Competing Interest Statement The authors have declared no competing interest.

Download data

  • Downloaded 35,012 times
  • Download rankings, all-time:
    • Site-wide: 149
    • In genomics: 8
  • Year to date:
    • Site-wide: 526
  • Since beginning of last month:
    • Site-wide: 394

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)