The major genetic risk factor for severe COVID-19 is inherited from Neandertals
By
Hugo Zeberg,
Svante Pääbo
Posted 03 Jul 2020
bioRxiv DOI: 10.1101/2020.07.03.186296
(published DOI: 10.1038/s41586-020-2818-3)
A recent genetic association study (Ellinghaus et al. 2020) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure in SARS-CoV-2. Recent data comprising 3,199 hospitalized COVID-19 patients and controls reproduce this and find that it is the major genetic risk factor for severe SARS-CoV-2 infection and hospitalization (COVID-19 Host Genetics Initiative). Here, we show that the risk is conferred by a genomic segment of ~50 kb that is inherited from Neandertals and occurs at a frequency of ~30% in south Asia and ~8% in Europe. ### Competing Interest Statement The authors have declared no competing interest.
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