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Pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection

By Qiannan Xu, Lihong Chen, Li Zhang, Mengyan Hu, Xiaopan Wang, Qi Yang, Yunchen Le, Feng Xue, Xia Li, Jie Zheng

Posted 01 Jul 2020
bioRxiv DOI: 10.1101/2020.06.30.181297

Since the end of 2019, COVID-19 pandemic caused by the SARS-CoV-2 emerged globally. The angiotensin-converting enzyme 2 (ACE2) on the cell surface is crucial for SARS-COV-2 entering into the cells. We use SARS-COV-2 pseudo virus and humanized ACE2 mice to mimic the possible transmitting of SARS-COV-2 through skin based on the data we found that skin ACE2 level is associated with skin pre-existing cutaneous conditions in human and mouse models and inflammatory skin disorders with barrier dysfunction increased the penetration of topical FITC conjugated spike protein into the skin. Our study indicated the possibility that the pre-existing cutaneous conditions could increase the risk for SARS-COV-2 infection. ![Figure][1]</img> ### Competing Interest Statement The authors have declared no competing interest. [1]: pending:yes

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