Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
David J. Wullimann,
Lars I Eriksson,
Niklas K Björkström,
Johan K. Sandberg,
David A. Price,
Karolinska COVID-19 Study Group
Posted 29 Jun 2020
bioRxiv DOI: 10.1101/2020.06.29.174888 (published DOI: 10.1016/j.cell.2020.08.017)
Posted 29 Jun 2020
SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed individuals as well as exposed family members and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative family members and individuals with a history of asymptomatic or mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals. ### Competing Interest Statement The authors have declared no competing interest.
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