Rxivist logo

Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors

By Pingtao Ding, Toshiyuki Sakai, Ram Krishna Shrestha, Nicolas Manosalva Perez, Wenbin Guo, Bruno Pok Man Ngou, Shengbo He, Chang Liu, Xiaoqi Feng, Runxuan Zhang, Klaas Vandepoele, Dan MacLean, Jonathan DG Jones

Posted 18 Jun 2020
bioRxiv DOI: 10.1101/2020.06.17.157040

Activation of cell Surface and Intracellular Receptor-Mediated Immunity (SRMI and IRMI) results in rapid transcriptional reprogramming that underpins disease resistance. However, the mechanisms by which SRMI and IRMI lead to transcriptional changes are not clear. Here, we combine RNA-seq and ATAC-seq to define changes in gene expression and chromatin accessibility; both SRMI and IRMI increase chromatin accessibility at induced defense genes. Analysis of ATAC-seq and RNA-seq data combined with publicly available information on transcription factor DNA-binding motifs enabled comparison of individual gene regulatory networks activated by SRMI and IRMI, and by both. These results and analyses reveal overlapping and conserved transcriptional regulatory mechanism between the two immune systems. ### Competing Interest Statement The authors have declared no competing interest.

Download data

  • Downloaded 1,110 times
  • Download rankings, all-time:
    • Site-wide: 22,823
    • In plant biology: 332
  • Year to date:
    • Site-wide: 14,839
  • Since beginning of last month:
    • Site-wide: 17,911

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide