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Personalized vagino-cervical microbiome dynamics after oral probiotics

By Chen Chen, Lilan Hao, Liu Tian, Liju Song, Xiaowei Zhang, Zhuye Jie, Xin Tong, Liang Xiao, Tao Zhang, Xin Jin, Xun Xu, Huanming Yang, Jian Wang, Guanghong Zhou, Huijue Jia

Posted 17 Jun 2020
bioRxiv DOI: 10.1101/2020.06.16.155929

The vaginal microbiota is presumably much simpler than the gut microbiome, and oral probiotics appear as a promising means to modulate its homeostasis in the general population. Here, 60 women were followed for over a year before, during and after a probiotic containing Lactobacillus rhamnosus GR-1 and L. reuteri RC-14. Shotgun metagenomic data of 1334 samples from multiple body sites did not support colonization of the probiotics to the vagino-cervical microbiome, yet the microbiome was stable in those dominated by Lactobacilli and some individuals have likely benefited from this medication-free intervention. ### Competing Interest Statement The authors have declared no competing interest.

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