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Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro

By Hua-Long Xiong, Jia-Li Cao, Chen-Guang Shen, Jian Ma, Xiao-Yang Qiao, Tian-Shu Shi, Yang Yang, Sheng-Xiang Ge, Jun Zhang, Tian-Ying Zhang, Quan Yuan, Ningshao Xia

Posted 05 Jun 2020
bioRxiv DOI: 10.1101/2020.06.05.135996

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM. ### Competing Interest Statement The authors have declared no competing interest.

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