Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.
Felix R. Day,
Felix C. Tropf,
David M. Brazel,
Natalie van Zuydam,
Bárbara D. Bitarello,
Marcel den Hoed,
Ken K. Ong,
Melinda C Mills,
John R.B. Perry,
on behalf of the Human Reproductive Behaviour Consortium
Posted 22 May 2020
bioRxiv DOI: 10.1101/2020.05.19.104455
Posted 22 May 2020
Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertility and also identify alleles under present-day selection. Using data in 785,604 individuals of European ancestry, we identify 43 genomic loci associated with either number of children ever born (NEB) or childlessness. These loci span diverse aspects of reproductive biology across the life course, including puberty timing, age at first birth, sex hormone regulation and age at menopause. Missense alleles in ARHGAP27 were associated with increased NEB but reduced reproductive lifespan, suggesting a trade-off between reproductive ageing and intensity. As NEB is one component of evolutionary fitness, our identified associations indicate loci under present-day natural selection. Accordingly, we find that NEB-increasing alleles have increased in frequency over the past two generations. Furthermore, integration with data from ancient selection scans identifies a unique example of an allele - FADS1/2 gene locus - that has been under selection for thousands of years and remains under selection today. Collectively, our findings demonstrate that diverse biological mechanisms contribute to reproductive success, implicating both neuro-endocrine and behavioural influences. ### Competing Interest Statement The authors have declared no competing interest.
- Downloaded 814 times
- Download rankings, all-time:
- Site-wide: 28,092
- In genetics: 1,366
- Year to date:
- Site-wide: 18,417
- Since beginning of last month:
- Site-wide: 20,687
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!