Tiger team: a panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Shmuel C. Shapira,
Posted 20 May 2020
bioRxiv DOI: 10.1101/2020.05.20.106609 (published DOI: 10.1038/s41467-020-18159-4)
Posted 20 May 2020
The novel highly transmissible human coronavirus SARS-CoV-2 is the causative agent of the COVID-19 pandemic. Thus far, there is no approved therapeutic drug, specifically targeting this emerging virus. Here we report the isolation and characterization of a panel of human neutralizing monoclonal antibodies targeting the SARS-CoV-2 receptor binding domain (RBD). These antibodies were selected from a phage display library constructed using peripheral circulatory lymphocytes collected from patients at the acute phase of the disease. These neutralizing antibodies are shown to recognize distinct epitopes on the viral spike RBD, therefore they represent a promising basis for the design of efficient combined post-exposure therapy for SARS-CoV-2 infection. ### Competing Interest Statement Patent application for the described antibodies was filed by the Israel Institute for Biological Research.
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