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Silent dissemination of plasmid-borne tigecycline resistance gene tet(X6) in livestock-associated Acinetobacter towneri

By Yingying Cheng, Yong Chen, Yang Liu, Jingjie Song, Yuqi Guo, Yanzi Zhou, Tingting Xiao, Shuntian Zhang, Hao Xu, Yunbo Chen, Tongling Shan, Yonghong Xiao, Kai Zhou

Posted 12 May 2020
bioRxiv DOI: 10.1101/2020.05.08.085514

A tigecycline-resistance gene, tet (X6), was detected on a 159-kb novel plasmid carried by a tigecycline-susceptible livestock-associated Acinetobacter towneri isolate. The genetic context of tet (X6) (ΔIS Vsa3-tet (X6)- abh-guaA -IS Vsa3 ) is highly similar with that of the other plasmid-borne tet (X) variants. The 23-Ala residue of the first FAD binding site conferred higher activity to Tet(X6) than the 23-Gly reside conserved in the other plasmid-borne tet (X)s. To our knowledge, this is the first report of tet (X6) carried by the plasmid.

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