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On spatial molecular arrangements of SARS-CoV2 genomes of Indian patients

By Sk. Sarif Hassan, Atanu Moitra, Ranjeet Kumar Rout, Pabitra Pal Choudhury, Prasanta Pramanik, Siddhartha Sankar Jana

Posted 01 May 2020
bioRxiv DOI: 10.1101/2020.05.01.071985

A pandemic caused by the SARS-CoV2 is being experienced by the whole world since December, 2019. A thorough understanding beyond just sequential similarities among the protein coding genes of SARS-CoV2 is important in order to differentiate or relate to the other known CoVs of the same genus. In this study, we compare three genomes namely MT012098 (India-Kerala), MT050493 (India-Kerala), MT358637 (India-Gujrat) from India with NC 045512 (China-Wuhan) to view the spatial as well as molecular arrangements of nucleotide bases of all the genes embedded in these four genomes. Based on different features extracted for each gene embedded in these genomes, corresponding phylogenetic relationships have been built up. Differences in phylogenetic tree arrangement with individual gene suggest that three genomes of Indian origin have come from three different origins or the evolution of viral genome is very fast process. This study would also help to understand the virulence factors, disease pathogenicity, origin and transmission of the SARS-CoV2. ### Competing Interest Statement The authors have declared no competing interest.

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