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HiChIP: Efficient and sensitive analysis of protein-directed genome architecture

By Maxwell R. Mumbach, Adam J. Rubin, Ryan A. Flynn, Chao Dai, Paul A. Khavari, William J. Greenleaf, Howard Y. Chang

Posted 08 Sep 2016
bioRxiv DOI: 10.1101/073619 (published DOI: 10.1038/nmeth.3999)

Genome conformation is central to gene control but challenging to interrogate. Here we present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield of conformation-informative reads by over 10-fold and lowers input requirement over 100-fold relative to ChIA-PET. HiChIP of cohesin reveals multi-scale genome architecture with greater signal to background than in situ Hi-C. Thus, HiChIP adds to the toolbox of 3D genome structure and regulation for diverse biomedical applications.

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