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Association of 4 epigenetic clocks with measures of functional health, cognition, and all-cause mortality in The Irish Longitudinal Study on Ageing (TILDA)

By Cathal McCrory, Giovanni Fiorito, Belinda Hernandez, Silvia Polidoro, Aisling M. O’Halloran, Ann Hever, Cliona Ni Cheallaigh, Ake T Lu, Steve Horvath, Paolo Vineis, Rose Anne Kenny

Posted 28 Apr 2020
bioRxiv DOI: 10.1101/2020.04.27.063164

The aging process is characterized by the presence of high interindividual variation between individuals of the same chronical age prompting a search for biomarkers that capture this heterogeneity. The present study examines the associations of four epigenetic clocks - Horvath, Hannum, PhenoAge, GrimAge - with a wide range of clinical phenotypes, and with all-cause mortality at up to 10-year follow-up in a sample of 490 participants in the Irish Longitudinal Study on Ageing (TILDA). Results indicate that the GrimAge clock represents a step-improvement in the predictive utility of the epigenetic clocks for identifying age-related decline in an array of clinical phenotypes. ### Competing Interest Statement The authors have declared no competing interest.

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