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Identification of pathogens in culture-negative infective endocarditis with metagenomic analysis

By Jun Cheng, Huan Hu, Yue Kang, Weizhi Chen, Wei Fang, Kaijuan Wang, Qian Zhang, Aisi Fu, Shuilian Zhou, Chen Cheng, Qingqing Cao, Fei-Yan Wang, Shela Lee, Zhou Zhou

Posted 02 Jun 2018
bioRxiv DOI: 10.1101/336388 (published DOI: 10.1186/s12941-018-0294-5)

Pathogen identification is critical for the proper diagnosis and precise treatment of infective endocarditis (IE). Although blood and valve cultures are the gold standard for infective endocarditis pathogen detection, many cases were culture-negative, especially in patients who had received long term antibiotics treatment, which has become a major challenge of its diagnosis in clinic. Metagenomic sequencing can provide both pathogen strain information and antibiotics susceptibility profiles of patient samples without culturing, offering a powerful method to deal with culture-negative cases. In this work, we assessed the feasibility of metagenomic approach to detect causative pathogens in resected valves from IE patients.

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