In this study, we developed an in-situ cellular reprogramming strategy for potent restoration of vision in advanced/end-stage retinitis pigmentosa (RP). Via repressing PTB, an RNA binding protein critical for converting non-neuronal cells to the neuronal lineage, we successfully reprogramed Muller glia to a retinal neuronal fate, and then to cones. We demonstrated that this cellular reprogramming approach was able to rescue retinal photoreceptor degeneration and restore visual functions in two RP mouse models with total blindness, suggesting a novel universal strategy for treating end-stage degenerative diseases. ### Competing Interest Statement

Download data

• Downloaded 797 times
• Download rankings, all-time:
  • Site-wide: 25,914
  • In cell biology: 961
• Year to date:
  • Site-wide: 22,690
• Since beginning of last month:
  • Site-wide: 24,494

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide