Genomic evaluation of circulating proteins for drug target characterisation and precision medicine
Daniel Hvidberg Hansen,
Åsa K. Hedman,
Daria V. Zhernakova,
Sarah E Bergen,
Jesper R Gådin,
Jeremy D Gale,
Seung Hoan Choi,
Federico de Masi,
Peter K. Joshi,
Cecilia M. Lindgren,
Andrew P Morris,
Peter M Nilsson,
Jim F Wilson,
Adam S. Butterworth,
Michael V Holmes,
Posted 06 Apr 2020
bioRxiv DOI: 10.1101/2020.04.03.023804
Posted 06 Apr 2020
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. By mapping and replicating protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, we identified 467 pQTLs for 85 proteins. The pQTLs were used in combination with other sources of information to evaluate known drug targets, and suggest new target candidates or repositioning opportunities, underpinned by a) causality assessment using Mendelian randomization, b) pathway mapping using trans-pQTL gene assignments, and c) protein-centric polygenic risk scores enabling matching of plausible target mechanisms to sub-groups of individuals enabling precision medicine.
- Downloaded 1,314 times
- Download rankings, all-time:
- Site-wide: 7,609 out of 92,738
- In genetics: 537 out of 4,748
- Year to date:
- Site-wide: 1,152 out of 92,738
- Since beginning of last month:
- Site-wide: 3,231 out of 92,738
Downloads over time
Distribution of downloads per paper, site-wide
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!