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Flexible multivariate linear mixed models for structured multiple traits

By Hyeonju Kim, Gregory Farage, John T. Lovell, John K. Mckay, Tom E Juenger, Saunak Sen

Posted 29 Mar 2020
bioRxiv DOI: 10.1101/2020.03.27.012690

Many genetic studies collect structured multivariate traits containing rich information across the traits. We present a flexible multivariate linear mixed model for Quantitative Trait Loci analysis (FlxQTL) incorporating trait covariates and a trait kernel to test genetic associations across multiple correlated traits while capturing genetic relatedness. FlxQTL effectively handles a trait across multi-environments, multi-time points, etc. enhancing computation speed.

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