Rxivist logo

Structural basis of ethnic-specific variants of PAX4 associated with type 2 diabetes

By Jun Hosoe, Ken Suzuki, Takashi Kato, Yukinori Okada, Momoko Horikoshi, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki

Posted 26 Mar 2020
bioRxiv DOI: 10.1101/2020.03.24.006254

Recently, we conducted genome-wide association studies of type 2 diabetes (T2D) in a Japanese population, which identified 20 novel T2D loci that were not associated with T2D in Europeans. Moreover, nine novel missense risk variants, such as those of PAX4, were not rare in the Japanese population, but rare in Europeans. We report in silico structural analysis of ethnic-specific variants of PAX4, which suggests the pathogenic effect of these variants.

Download data

  • Downloaded 89 times
  • Download rankings, all-time:
    • Site-wide: 87,508 out of 93,433
    • In genetics: 4,554 out of 4,776
  • Year to date:
    • Site-wide: 52,605 out of 93,433
  • Since beginning of last month:
    • Site-wide: 56,229 out of 93,433

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News