Rxivist logo

Functional analysis of the chromosomal passenger complex in Arabidopsis

By Shinichiro Komaki, Hidenori Takeuchi, Yuki Hamamura, Maren Heese, Takashi Hashimoto, Arp Schnittger

Posted 20 Mar 2020
bioRxiv DOI: 10.1101/2020.03.19.998880

A key regulator of cell division in all eukaryotes is the kinase Aurora B, which is encoded by the Aurora 3 (AUR3) gene in Arabidopsis. Aurora B has at least two central functions during cell division. On the one hand, it is essential for the correct, i.e. balanced, segregation of chromosomes in mitosis and meiosis by controlling kinetochore function. On the other hand, Aurora B acts at the division plane, where it is necessary to complete cytokinesis. To accomplish these two spatially distinct functions, Aurora B in animals is guided to its sites of action by Borealin, INCENP, and Survivin that build together with Aurora B the chromosome passenger complex (CPC). However, besides Aurora homologs, only a candidate gene with restricted homology to INCENP has so far been described in Arabidopsis raising the question whether there exists a full complement of the CPC in plants and how Aurora homologs are targeted subcellularly. Here, we have identified and functionally characterized a Borealin homolog, BOREALIN RELATED (BORR), in Arabidopsis. This, together with detailed localization studies including the putative Arabidopsis INCENP homolog, supports the existence of a CPC in plants.

Download data

  • Downloaded 358 times
  • Download rankings, all-time:
    • Site-wide: 105,546
    • In cell biology: 4,872
  • Year to date:
    • Site-wide: 144,967
  • Since beginning of last month:
    • Site-wide: 166,937

Altmetric data

Downloads over time

Distribution of downloads per paper, site-wide