Whole Genome Sequencing in Psychiatric Disorders: the WGSPD Consortium
Donna M. Werling,
Whole Genome Sequencing for Psychiatric Disorders,
P. Alexander Arguello,
Mark J. Daly,
Daniel H. Geschwind,
David C. Glahn,
David B. Goldstein,
Raquel E. Gur,
Robert E Handsaker,
Steven A McCarroll,
Roel A. Ophoff,
Matthew W. State,
A. Jeremy Willsey,
Steven E. Hyman,
Anjene M. Addington,
Nelson B. Freimer
Posted 07 Jul 2017
bioRxiv DOI: 10.1101/160499 (published DOI: 10.1038/s41593-017-0017-9)
Posted 07 Jul 2017
As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative cost and utility. Variants identified uniquely through WGS may reveal novel biological pathways underlying complex disorders and provide high-resolution insight into when, where, and in which cell type these pathways are affected. Alternatively, cheaper and less computationally intensive approaches may yield equivalent insights. Understanding the role of rare variants in the noncoding gene-regulating genome, through pilot WGS projects, will be critical to determine which of these two extremes best represents reality. With large cohorts, well-defined risk loci, and a compelling need to understand the underlying biology, psychiatric disorders have a role to play in this preliminary WGS assessment. The WGSPD consortium will integrate data for 18,000 individuals with psychiatric disorders, beginning with autism spectrum disorder, schizophrenia, bipolar disorder, and major depressive disorder, along with over 150,000 controls.
- Downloaded 1,721 times
- Download rankings, all-time:
- Site-wide: 10,718
- In genomics: 1,116
- Year to date:
- Site-wide: 80,071
- Since beginning of last month:
- Site-wide: 127,751
Downloads over time
Distribution of downloads per paper, site-wide
- 27 Nov 2020: The website and API now include results pulled from medRxiv as well as bioRxiv.
- 18 Dec 2019: We're pleased to announce PanLingua, a new tool that enables you to search for machine-translated bioRxiv preprints using more than 100 different languages.
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!