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Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B

By Amanda M Casto, Meei-Li Huang, Hong Xie, Keith R Jerome, Anna Wald, Christine Johnston, Alexander Greninger

Posted 26 Feb 2020
bioRxiv DOI: 10.1101/2020.02.25.965426 (published DOI: 10.3390/v12080860)

Human herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics.

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