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A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo

By Jinxia Wan, Wanling Peng, Xuelin Li, Tongrui Qian, Kun Song, Jianzhi Zeng, Fei Deng, Suyu Hao, Jiesi Feng, Peng Zhang, Yajun Zhang, Jing Zou, Sunlei Pan, J. Julius Zhu, Miao Jing, Min Xu, Yulong Li

Posted 25 Feb 2020
bioRxiv DOI: 10.1101/2020.02.24.962282

Serotonin (5-HT) is a phylogenetically conserved monoamine neurotransmitter modulating a variety of processes in the brain. To directly visualize the dynamics of 5-HT, we developed a genetically encoded GPCR-Activation-Based 5-HT (GRAB5-HT) sensor with high sensitivity, selectivity, and spatiotemporal resolution. GRAB5-HT, detected 5-HT release in multiple physiological and pathological conditions in both flies and mice, and thus provides new insights into the dynamics and mechanisms of 5-HT signaling.

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