Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates
Christopher A Cottrell,
Jelle van Schooten,
Charles A. Bowman,
Patricia van der Woude,
Marielle van Breemen,
Jonathan L. Torres,
Leigh M. Sewall,
Eva G Rakasz,
Diane G. Carnathan,
D. Noah Sather,
Dennis R. Burton,
John P Moore,
Ian A. Wilson,
Rogier W. Sanders,
Andrew B. Ward,
Marit J. van Gils
Posted 07 Feb 2020
bioRxiv DOI: 10.1101/2020.02.05.936096 (published DOI: 10.1371/journal.ppat.1008753)
Posted 07 Feb 2020
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce potent autologous neutralizing responses in rabbits and non-human primates. In this study, monoclonal antibodies were isolated and characterized from rhesus macaques immunized with the BG505 SOSIP.664 trimer to better understand vaccine-induced antibody responses. Our studies reveal a diverse landscape of antibodies recognizing immunodominant strain-specific epitopes and non-neutralizing neo-epitopes. Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.
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