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Replication timing shapes the cancer epigenome and the nature of chromosomal rearrangements

By Qian Du, Saul A Bert, Nicola J. Armstrong, C Elizabeth Caldon, Jenny Z Song, Shalima S Nair, Cathryn M Gould, Phuc Loi Luu, Amanda Khoury, Wenjia Qu, Elena Zotenko, Clare Stirzaker, Susan J. Clark

Posted 22 Jan 2018
bioRxiv DOI: 10.1101/251280

Replication timing is known to facilitate the establishment of epigenome, however, the intimate connection between DNA replication timing and changes to the genome and epigenome in cancer remain uncharted. Here, we perform Repli-Seq and integrated epigenome analysis and show that early-replicating loci are predisposed to hypermethylation and late-replicating loci to hypomethylation, enrichment of H3K27me3 and concomitant loss of H3K9me3. We find that altered replication timing domains correspond to long-range epigenetically deregulated regions in prostate cancer, and a subset of these domains are remarkably conserved across cancers from different tissue origins. Analyses of 214 prostate and 35 breast cancer genomes reveal that late-replicating DNA is prone to cis and early- replicating DNA to trans chromosomal rearrangements. We propose that differences in epigenetic deregulation related to spatial and temporal positioning between early and late replication potentiate the landscape of chromosomal rearrangements in cancer.

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