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A minimum reporting standard for multiple sequence alignments

By Thomas KF Wong, Subha Kalyaanamoorthy, Karen Meusemann, David K Yeates, Bernhard Misof, Lars S Jermiin

Posted 15 Jan 2020
bioRxiv DOI: 10.1101/2020.01.15.907733 (published DOI: 10.1093/nargab/lqaa024)

Multiple sequence alignments (MSAs) play a pivotal role in studies of molecular sequence data, but nobody has developed a minimum reporting standard (MRS) to quantify the completeness of MSAs in terms of completely-specified nucleotides or amino acids. We present an MRS that relies on four simple completeness metrics. The metrics are implemented in AliStat, a program developed to support the MRS. A survey of published MSAs illustrates the benefits and unprecedented transparency offered by the MRS.

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