Molecular Choreography of Acute Exercise
By
Kévin Contrepois,
Si Wu,
Kegan J Moneghetti,
Daniel Hornburg,
Sara Ahadi,
Ming-Shian Tsai,
Ahmed A Metwally,
Eric Wei,
Brittany Lee-McMullen,
Jeniffer V Quijada,
Songjie Chen,
Jeffrey W. Christle,
Mathew Ellenberger,
Brunilda Balliu,
Shalina Taylor,
Matthew Durrant,
David A. Knowles,
Hany Choudhry,
Melanie Ashland,
Amir Bahmani,
Brooke Enslen,
Myriam Amsallem,
Yukari Kobayashi,
Monika Avina,
Dalia Perelman,
Sophia Miryam Schüssler-Fiorenza Rose,
Wenyu Zhou,
Euan A. Ashley,
Stephen B. Montgomery,
Hassan Chaib,
Francois Haddad,
Michael P. Snyder
Posted 14 Jan 2020
bioRxiv DOI: 10.1101/2020.01.13.905349
(published DOI: 10.1016/j.cell.2020.04.043)
Exercise testing is routinely used in clinical practice to assess fitness - a strong predictor of survival - as well as causes of exercise limitations. While these studies often focus on cardiopulmonary response and selected molecular pathways, the dynamic system-wide molecular response to exercise has not been fully characterized. We performed a longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including transcriptome, immunome, proteome, metabolome and lipidome in 36 well-characterized volunteers before and after a controlled bout of acute exercise (2, 15, 30 min and 1 hour in recovery). Integrative analysis revealed an orchestrated choreography of biological processes across key tissues. Most of these processes were dampened in insulin resistant participants. Finally, we discovered biological pathways involved in exercise capacity and developed prediction models revealing potential resting blood-based biomarkers of fitness.
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