Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 63,093 bioRxiv papers from 279,869 authors.
Biological and clinical insights from genetics of insomnia symptoms
Jacqueline M. Lane,
Andrew R Wood,
Vincent T. van Hees,
Bendik Slagsvold Winsvold,
Simon G. Anderson,
David A. Bechtold,
Max A. Little,
Annemarie I I. Luik,
Andrew S. Loudon,
Rebecca C. Richmond,
Frank AJL Scheer,
HUNT All In Sleep,
Linn B. Strand,
Jonas B. Nielsen,
Cristen J. Willer,
Simon D. Kyle,
David W. Ray,
John Anker Zwart,
Timothy M Frayling,
Martin K. Rutter,
Michael N Weedon,
Posted 02 Feb 2018
bioRxiv DOI: 10.1101/257956 (published DOI: 10.1038/s41588-019-0361-7)
Posted 02 Feb 2018
Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes, but underlying pathophysiological processes and causal relationships with disease are poorly understood. Here we identify 57 loci for self-reported insomnia symptoms in the UK Biobank (n=453,379) and confirm their impact on self-reported insomnia symptoms in the HUNT study (n=14,923 cases, 47,610 controls), physician diagnosed insomnia in Partners Biobank (n=2,217 cases, 14,240 controls), and accelerometer-derived measures of sleep efficiency and sleep duration in the UK Biobank (n=83,726). Our results suggest enrichment of genes involved in ubiquitin-mediated proteolysis, phototransduction and muscle development pathways and of genes expressed in multiple brain regions, skeletal muscle and adrenal gland. Evidence of shared genetic factors is found between frequent insomnia symptoms and restless legs syndrome, aging, cardio-metabolic, behavioral, psychiatric and reproductive traits. Evidence is found for a possible causal link between insomnia symptoms and coronary heart disease, depressive symptoms and subjective well-being.
- Downloaded 1,197 times
- Download rankings, all-time:
- Site-wide: 5,283 out of 63,093
- In genomics: 902 out of 4,333
- Year to date:
- Site-wide: 5,213 out of 63,093
- Since beginning of last month:
- Site-wide: 21,838 out of 63,093
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!