Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 52,506 bioRxiv papers from 243,425 authors.
DNA methylation age acceleration and risk factors for Alzheimer's disease
Daniel L McCartney,
Anna J Stevenson,
Rosie M Walker,
Stewart W Morris,
Alison D Murray,
Heather C Whalley,
David J Porteous,
Andrew M McIntosh,
Kathryn L Evans,
Ian J Deary,
Riccardo E Marioni
Posted 08 Mar 2018
bioRxiv DOI: 10.1101/278945 (published DOI: 10.1016/j.dadm.2018.05.006)
Posted 08 Mar 2018
INTRODUCTION: The 'epigenetic clock' is a DNA methylation based estimate of biological age and is correlated with chronological age: the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. Here, we assess the relationship associations between the epigenetic clock and AD risk factors. METHODS: Linear mixed modelling was used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n=5,100). RESULTS: We report significant associations between the epigenetic clock and BMI, total:HDL cholesterol ratios, socioeconomic status, and smoking behaviour (Bonferroni adjusted P<0.05). DISCUSSION: Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.
- Downloaded 391 times
- Download rankings, all-time:
- Site-wide: 20,320 out of 52,506
- In genomics: 2,318 out of 3,756
- Year to date:
- Site-wide: 19,223 out of 52,506
- Since beginning of last month:
- Site-wide: 23,961 out of 52,506
Downloads over time
Distribution of downloads per paper, site-wide
- Top preprints of 2018
- Paper search
- Author leaderboards
- Overall metrics
- The API
- Email newsletter
- 21 May 2019: PLOS Biology has published a community page about Rxivist.org and its design.
- 10 May 2019: The paper analyzing the Rxivist dataset has been published at eLife.
- 1 Mar 2019: We now have summary statistics about bioRxiv downloads and submissions.
- 8 Feb 2019: Data from Altmetric is now available on the Rxivist details page for every preprint. Look for the "donut" under the download metrics.
- 30 Jan 2019: preLights has featured the Rxivist preprint and written about our findings.
- 22 Jan 2019: Nature just published an article about Rxivist and our data.
- 13 Jan 2019: The Rxivist preprint is live!