Rxivist logo

GWAS of erectile dysfunction (ED) in 6,175 cases among 223,805 European men identified one new locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71×10-14), located between MCHR2 and SIM1. In-silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation; Mendelian randomization indicates genetic risk of type 2 diabetes causes ED. Our findings provide novel insights into the biological underpinnings of ED.

Download data

  • Downloaded 862 times
  • Download rankings, all-time:
    • Site-wide: 15,015 out of 92,091
    • In genomics: 1,938 out of 5,810
  • Year to date:
    • Site-wide: 80,643 out of 92,091
  • Since beginning of last month:
    • Site-wide: 74,963 out of 92,091

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News