Rxivist logo

Rxivist combines preprints from bioRxiv with data from Twitter to help you find the papers being discussed in your field. Currently indexing 57,822 bioRxiv papers from 266,142 authors.

A polygenic p factor for major psychiatric disorders

By Saskia Selzam, Jonathan R. I. Coleman, Terrie E Moffitt, Avshalom Caspi, Robert Plomin

Posted 23 Mar 2018
bioRxiv DOI: 10.1101/287987 (published DOI: 10.1038/s41398-018-0217-4)

It has recently been proposed that a single dimension, called the p factor, can capture a person's liability to mental disorder. Relevant to the p hypothesis, recent genetic research has found surprisingly high genetic correlations between pairs of psychiatric disorders. Here, for the first time we compare genetic correlations from different methods and examine their support for a genetic p factor. We tested the hypothesis of a genetic p factor by using principal component analysis on matrices of genetic correlations between major psychiatric disorders estimated by three methods - family study, Genome-wide Complex Trait Analysis, and Linkage-Disequilibrium Score Regression - and on a matrix of polygenic score correlations constructed for each individual in a UK-representative sample of 7,026 unrelated individuals. All disorders loaded on a first unrotated principal component, which accounted for 57%, 43%, 34% and 19% of the variance respectively for each method. Our results showed that all four methods provided strong support for a genetic p factor that represents the pinnacle of the hierarchical genetic architecture of psychopathology.

Download data

  • Downloaded 850 times
  • Download rankings, all-time:
    • Site-wide: 8,416 out of 57,822
    • In genomics: 1,292 out of 4,058
  • Year to date:
    • Site-wide: 29,924 out of 57,822
  • Since beginning of last month:
    • Site-wide: 46,422 out of 57,822

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News