STREAM: Single-cell Trajectories Reconstruction, Exploration And Mapping of omics data
Jonathan Y Hsu,
Caleb A. Lareau,
Giosue` Lo Bosco,
Alexander N Gorban,
Daniel E Bauer,
Martin J. Aryee,
David M. Langenau,
Jason D Buenrostro,
Posted 18 Apr 2018
bioRxiv DOI: 10.1101/302554 (published DOI: 10.1038/s41467-019-09670-4)
Posted 18 Apr 2018
Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage differentiation trajectories, along with the characterization of cellular heterogeneity and state transitions. Several methods have been developed for reconstructing developmental trajectories from single-cell transcriptomic data, but efforts on analyzing single-cell epigenomic data and on trajectory visualization remain limited. Here we present STREAM, an interactive pipeline capable of disentangling and visualizing complex branching trajectories from both single-cell transcriptomic and epigenomic data.
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