Rxivist logo

Despite food choices being one of the most important factors influencing health, efforts to identify individual food groups and dietary patterns that cause disease have been challenging, with traditional nutritional epidemiological approaches plagued by biases and confounding. After identifying 302 (289 novel) individual genetic determinants of dietary intake in 445,779 individuals in the UK Biobank study, we develop a statistical genetics framework that enables us, for the first time, to directly assess the impact of food choices on health outcomes. We show that the biases which affect observational studies extend also to GWAS, genetic correlations and causal inference through genetics, which can be corrected by applying our methods. Finally, by applying Mendelian Randomization approaches to the corrected results we identify some of the first robust causal associations between eating patterns and risks of cancer, heart disease and obesity, distinguishing between the effects of specific foods or dietary patterns.

Download data

  • Downloaded 803 times
  • Download rankings, all-time:
    • Site-wide: 15,196 out of 84,908
    • In genetics: 985 out of 4,454
  • Year to date:
    • Site-wide: 6,004 out of 84,908
  • Since beginning of last month:
    • Site-wide: 12,903 out of 84,908

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News