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A MAP of tumor-host interactions in glioma at single cell resolution

By Francesca Pia Caruso, Luciano Garofano, Fulvio D’Angelo, Kai Yu, Fuchou Tang, Jinzhou Yuan, Jing Zhang, Luigi Cerulo, Davide Bedognetti, Peter A. Sims, Mario Suvà, Xiao-Dong Su, Anna Lasorella, Antonio Iavarone, Michele Ceccarelli

Posted 01 Nov 2019
bioRxiv DOI: 10.1101/827758 (published DOI: 10.1093/gigascience/giaa109)

Single-cell RNA sequencing is the reference technique to characterize the heterogeneity of tumor microenvironment and can be efficiently used to discover cross-talk mechanisms between immune cells and cancer cells. We present a novel method, single cell Tumor-Host Interaction tool (scTHI), to identify significantly activated ligand-receptor interactions across clusters of cells from single-cell RNA sequencing data. We apply our approach to uncover the ligand-receptor interactions in glioma using six publicly available human glioma datasets encompassing 71 patients. We provide a comprehensive map of the signalling mechanisms between malignant cells and non-malignant cells in glioma uncovering potential novel therapeutic targets.

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