A MAP of tumor-host interactions in glioma at single cell resolution
Francesca Pia Caruso,
Peter A. Sims,
Posted 01 Nov 2019
bioRxiv DOI: 10.1101/827758 (published DOI: 10.1093/gigascience/giaa109)
Posted 01 Nov 2019
Single-cell RNA sequencing is the reference technique to characterize the heterogeneity of tumor microenvironment and can be efficiently used to discover cross-talk mechanisms between immune cells and cancer cells. We present a novel method, single cell Tumor-Host Interaction tool (scTHI), to identify significantly activated ligand-receptor interactions across clusters of cells from single-cell RNA sequencing data. We apply our approach to uncover the ligand-receptor interactions in glioma using six publicly available human glioma datasets encompassing 71 patients. We provide a comprehensive map of the signalling mechanisms between malignant cells and non-malignant cells in glioma uncovering potential novel therapeutic targets.
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