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Varying Effects of Common Tuberculosis Drugs on Enhancing Clofazimine Activity in vitro

By Shuo Zhang, Wanliang Shi, Jie Feng, Wenhong Zhang, Ying Zhang

Posted 05 Mar 2017
bioRxiv DOI: 10.1101/112573 (published DOI: 10.1038/emi.2017.24)

There is recent interest in understanding how clofazimine (CFZ) might be involved in shortening the treatment of both MDR-TB and drug-susceptible TB. The present study made a number of interesting observations that may help explain the unique ability of CFZ to shorten TB therapy, by demonstrating acid pH enhancement of CFZ activity, the varying degrees of enhancement of CFZ activity against stationary phase bacilli by different TB drugs, with PZA and RIF having the highest degree of enhancement, followed by quinolones (moxifloxacin and levofloxacin), amikacin and PAS. Future studies are needed to validate our in vitro findings in animal models of TB infection.

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