Rxivist logo

Non-invasive stimulation of vagal afferents reduces gastric frequency

By Vanessa Teckentrup, Sandra Neubert, João C. P. Santiago, Manfred Hallschmid, Martin Walter, Nils B. Kroemer

Posted 25 Sep 2019
bioRxiv DOI: 10.1101/773259 (published DOI: 10.1016/j.brs.2019.12.018)

Metabolic feedback between the gut and the brain relayed via the vagus nerve contributes to energy homeostasis. We investigated in healthy adults whether non-invasive stimulation of vagal afferents impacts energy homeostasis via efferent effects on metabolism or digestion. In a randomized crossover design, we applied transcutaneous auricular vagus nerve stimulation (taVNS) while recording efferent metabolic effects using simultaneous electrogastrography (EGG) and indirect calorimetry. We found that taVNS reduced gastric myoelectric frequency (p = .008), but did not alter resting energy expenditure. We conclude that stimulating vagal afferents induces gastric slowing via vagal efferents without acutely affecting net energy expenditure at rest. Collectively, this highlights the potential of taVNS to modulate digestion by activating the dorsal vagal complex. Thus, taVNS-induced changes in gastric frequency are an important peripheral marker of brain stimulation effects.

Download data

  • Downloaded 199 times
  • Download rankings, all-time:
    • Site-wide: 58,315 out of 76,870
    • In neuroscience: 10,456 out of 13,776
  • Year to date:
    • Site-wide: 59,205 out of 76,870
  • Since beginning of last month:
    • Site-wide: 64,686 out of 76,870

Altmetric data


Downloads over time

Distribution of downloads per paper, site-wide


PanLingua

Sign up for the Rxivist weekly newsletter! (Click here for more details.)


News